Named for their capability of killing target cells autonomously, natural killer (NK) cells serve as the main effector cells toward cancer in innate immunity and are highly heterogeneous in the microenvironment. 1 Includes novel combinations and additional indications for assets where the lead is not yet launched. The tumor microenvironment is highly complex, and immune escape is currently considered an important hallmark of cancer, largely contributing to tumor progression and metastasis. IPHA +11.4% (doses first patient in Monalizumab Phase 3 clinical trial; triggers milestone payment) CVAC +7.6% (announces data from preclinical studies of its investigational SARS-CoV-2 vaccine candidate, CVnCoV, in mice and hamsters) KZR +6% (granted FDA Orphan Drug Designations for KZR-616 for the treatment of polymyositis and dermatomyositis) LoRusso, P. M. (2005). Q4 2020 new molecular entity (NME)1 pipeline Phase progressions based on first patient dose achievement. 4 # Partnered and/or in collaboration; ¶ Registrational Phase II/III trial Oncology Precision medicine approach being explored Phase I Phase II Phase III The investigator-sponsored Phase 2 clinical trial, FORCE (FORCOVID-19 Elimination), has completed enrollment and is ongoing for patient follow-up … Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 213 design. CLINICAL CANCER RESEARCH, 11(17), 6233–39.
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