Deficits were not apparent on tests of fine motor speed, vocabulary, reasoning and global functioning. Furthermore, therapist effects were not considered, due to lack of power and results from our previous study in the same setting which suggested therapist effects were minimal.30 Future studies should include a waiting list control sample within naturalistic settings to address these issues. 2014. 2013. The majority had 9–16 sessions (67.1%), 8.2% had 4 or less and 11.7% had 16 or more sessions. MAES, MICHAEL This naturalistic outcome study investigated the impact of individual cognitive behavioural therapy on patients' self-reported fatigue and physical functioning, after outpatient treatment for chronic fatigue syndrome. Current IQ scores of CFS adolescents were lower than expected on the basis of their school level. 2018 Dec;89(12):1308-1319. doi: 10.1136/jnnp-2017-317823. TC reports grants from UK National Institute for Health Research, Guy's and St Thomas' Charity. Duffy, Tim Hutchinson, Claire V. Prochalska, Camila Patients largely self-reported that they saw an improvement in their fatigue at discharge, with 87% reporting that they felt at least a little better; only 2.5% felt like they were worse off. These findings support the growing evidence from previous randomised control trials and suggest that cognitive behavioural therapy could be an effective treatment in routine treatment settings. Chronic fatigue syndrome and depression: cause, effect or covariate, The neuropsychological dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report, International Journal of Psychiatry in Medicine, Effects of exercise on cognitive and motor function in chronic fatigue syndrome and depression, Journal of Neurology, Neurosurgery, and Psychiatry, Neuropsychological deficits in patients with chronic fatigue syndrome, Journal of the International Neuropsychological Society, Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome, Probing the working memory system in chronic fatigue syndrome: a functional magnetic resonance imaging study using the n-back task, Differentiating simple versus complex processing speed: influence on new learning and memory performance, Journal of Clinical and Experimental Neuropsychology, Relation between neuropsychological impairment and functional disability in patients with chronic fatigue syndrome. Evaluation of criterion-based validity: results from normative population, The hospital anxiety and depression scale, The validity of the Hospital Anxiety and Depression Scale. and Cognitive compromise following exercise in monozygotic twins discordant for chronic fatigue syndrome: fact or artifact? View all Google Scholar citations At 18 months to 5 years, one-third of participants were not severely fatigued and almost three-quarters had good levels of physical functioning.14, Research suggests that older age has been consistently shown to be a predictor of poor outcomes.11,12,15 Furthermore, worse social adjustment, catastrophising and depression all predicted poor outcomes in patients with chronic fatigue syndrome in a specialist clinic.15 Baseline physical functioning (36-item Short Form Health Survey) and increased levels of pain predicted poor outcomes in a large study across six specialist units.12 However, duration of illness, counter-intuitively, was not a predictor of outcome regardless of setting.12,16–18. 2020 Apr 30;15(4):e0232475. Access to society journal content varies across our titles. However, the lack of a control condition limits us from drawing any causal inferences, as we cannot be certain that the improvements seen are due to cognitive behavioural therapy alone and not any other extraneous variables. The authors would like to thank all the patients and staff at the South London and Maudsley Persistent Physical Symptoms Research and Treatment Unit for their contribution to this research. Although relating to very different concepts, sleepiness and fatigue are often confounded. Zerr, Danielle M.

In addition, effect size of change in outcomes from start to end of treatment was estimated using Cohen's d (|d|).27 The effect size estimates were interpreted as small (|d| ≥ 0.2), medium (|d| ≥ 0.5) and large (|d| ≥ 0.8). Figure 1. Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy): diagnosis and management | 1-recommendations | Guidance and guidelines | NICE. The effect size was medium (|d| = 0.61) with a mean difference of 5.55 [95% confidence interval (4.79–6.32)]. The impact of chronic fatigue syndrome on cognitive functioning in adolescents. and We also found a significant regression equation for 36-item Short Form Health Survey improvement scores (F(8,430) = 6.18, p < 0.001), with an R2 of 0.103. Knoop, H, Bleijenberg, G, Gielissen, MFM. Patients who did not complete discharge or follow-up measures were considered to have dropped out from treatment. She has delivered workshops on medically unexplained symptoms, during the conduct of the study (money paid into King’s College London for future research). Malouff, JM, Thorsteinsson, EB, Rooke, SE, Bhullar, N, Schutte, NS. ,{i:'table4-0141076820951545',type:'table-wrap',g:[{m:'10.1177_0141076820951545-table4.gif',l:'10.1177_0141076820951545-table4.jpeg',size:'111 KB'}]} Fischer, David B. All participants received cognitive behavioural therapy with a mean duration of 12 sessions (standard deviation 4.9; range 1–30). Patients were largely very satisfied with their cognitive behavioural therapy treatment with over 90% of patients rating their satisfaction as at least slightly satisfied and 45% saying they were very satisfied.

and However, both fatigue-associated conditions such as the chronic fatigue syndrome (CFS) and sleepiness-associated conditions such as the sleep apnea-hypopnea syndrome (SAHS) are associated with cognitive impairment with impaired attention, concentration and memory performances. Avellaneda Fernández, Alfredo 2018 Feb;27(2):321-332. doi: 10.1007/s11136-017-1671-9. and  |  Sharing links are not available for this article. Alegre, José They must also report four or more of the following symptoms: impaired memory or concentration, sore throat, tender cervical or axillary lymph nodes, muscle pain, multi-joint pain, headaches, unrefreshing sleep and post-exertional malaise lasting for more than one day. Audit approval was provided by the Psychological Medicine Clinical Academic Group (ID number PPF191115) at the South London and Maudsley Hospital. Please enable it to take advantage of the complete set of features! Login failed.

At three-month follow-up, 84% reported at least some improvement and only 5% reporting feeling worse. Is a full recovery possible after cognitive behavioural therapy for chronic fatigue syndrome? A higher score indicates better physical functioning. Persons with CFS demonstrate moderate to large impairments in simple and complex information processing speed and in tasks requiring working memory over a sustained period of time.

Fatigue- and sleepiness-associated conditions can both present with significant and objective impairment of cognitive functioning and behavioural motor performance. Tummers, Marcia and Medow, Marvin S. NIH Finally, we found a significant regression equation for Work and Social Adjustment Scale improvement scores (F(8,438) = 7.63, p < 0.001), with an R2 of 0.122. Find out about Lean Library here, If you have access to journal via a society or associations, read the instructions below. HHS Estimated marginal means and standard errors for main outcomes over time. The views expressed in this article are those of the authors and not necessarily those of the National Institute for Health Research or the NHS. and 2008 Dec;17(4):427-31. doi: 10.1111/j.1365-2869.2008.00679.x. 2010. Anxiety and Depression was measured using the Hospital Anxiety and Depression Scale.24 The Hospital Anxiety and Depression Scale is a 14-item self-report questionnaire with seven questions assessing severity of each disorder-related symptom over the past week. Participants had been ill for a mean duration of 6.65 years (standard deviation 6.48); 437 (44%) were married or living together and 423 (43%) were single. Simply select your manager software from the list below and click on download. The current study therefore conducted a meta-analysis of research examining cognitive functioning in persons with CFS in order to identify the pattern and magnitude of any deficits that are associated with this condition. Treatment was based on the protocol outlined in previous randomised control trials19 and has remained fairly consistent across the years. ARNOLDUS, ROBERT J. W. However, only baseline Chalder Fatigue Questionnaire was positively correlated more than r = 0.3 with Chalder Fatigue Questionnaire improvement and accounts for the majority of the model. A multiple linear regression was used to predict improvement in Chalder Fatigue Questionnaire, Work and Social Adjustment Scale, and 36-item Short Form Health Survey scores, with improvement defined as the difference between patients’ computed follow-up scores and their start of treatment scores. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Sáez, Naia TWISK, FRANK N. M.

conducted a long-term follow-up of four groups of patients with chronic fatigue syndrome who had received cognitive behavioural therapy. Patients were excluded from the analysis if they had received home-based treatment, if they were still in active treatment at the time of analysis, if they had received a treatment other than cognitive behavioural therapy or if they had not completed a pre-treatment questionnaire measure. Improvement in patients' scores was statistically significant across each time point from start to end of treatment (p < 0.001) and then treatment improvements were sustained at follow-up with the difference in scores from discharge to follow-up being non-significant (mean difference = 0.37, p = 1). 2014. Badham, Stephen P. Predictors of outcome were assessed using the following variables: age, ethnicity (dichotomous), illness duration, and baseline fatigue, Work and Social Adjustment Scale, 36-item Short Form Health Survey, and Hospital Anxiety and Depression Scale.

This site needs JavaScript to work properly. In this large cohort, changes occurred within the first four sessions. NICE.

Members of _ can log in with their society credentials below, James Adamson, Sheila Ali, Alastair Santhouse, Simon Wessely, and Trudie Chalder, article is distributed under the terms of the Creative Commons Attribution 4.0 License (. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.

Using a linear mixed effects model, we can note that there was a significant main effect of time on patients Chalder Fatigue Questionnaire scores, F(4,2069) = 150.88, p < 0.001 with Chalder Fatigue Questionnaire significantly improving over time: start of treatment M = 24.20 (standard deviation = 6.95); end of treatment M = 17.42 (standard deviation = 8.83).


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